
Experience a luxurious twist on classic pasta with this Buffalo Chicken Alfredo Penne. This creative dish combines smooth, creamy Alfredo sauce with zesty buffalo chicken for a memorable meal. The tender penne pasta, juicy shredded chicken, and rich cheese sauce work together perfectly, making every bite irresistible.
As a family favorite, this recipe consistently delivers outstanding results. The combination of flavors appeals to even those who typically avoid spicy foods, making it a reliable choice for gatherings.
Key Ingredients
- Penne Pasta: Ridged pasta works best for maximum sauce adhesion
- Heavy Cream: The essential base for a silky smooth sauce
- Buffalo Sauce: Frank's RedHot recommended for optimal flavor
- Parmesan and Mozzarella: Freshly grated for best melting properties
- Chicken: Rotisserie or poached breast meat work equally well
Preparation Method
- Cook Pasta:
- Boil penne in salted water until al dente, approximately 11 minutes
- Prepare Sauce Base:
- Melt butter, sauté garlic until fragrant, about 1 minute
- Make Sauce:
- Add cream while whisking, incorporate buffalo sauce and seasonings until thickened
- Add Cheese:
- Gradually stir in cheeses until completely melted and smooth
- Combine:
- Mix in chicken and pasta until thoroughly coated with sauce

The buffalo sauce component adds the perfect level of heat while complementing the creamy base. Frank's RedHot Buffalo sauce consistently produces excellent results in this recipe.
Serving Suggestions
Serve with crispy garlic bread and fresh Caesar salad. Roasted vegetables like Brussels sprouts or asparagus make excellent side dishes.
Recipe Variations
Try substituting shrimp for chicken or adding sautéed mushrooms. For a lighter version, half-and-half can replace heavy cream.
Storage Instructions
Store leftovers in an airtight container up to three days. Reheat gently with a splash of cream, stirring occasionally.
This Buffalo Chicken Alfredo Penne combines classic comfort with bold flavors. Its straightforward preparation and reliable results make it a standout recipe for any occasion.

Frequently Asked Questions
- → How spicy is this recipe?
- It’s got a nice kick, but you can easily adjust by adding less buffalo sauce or more if you like it hot!
- → Does rotisserie chicken work here?
- Absolutely, it’s a time-saver. Just shred and toss it into the sauce when you’re ready.
- → What can I pair with this pasta?
- Try a crisp green salad or roasted veggies to lighten up the richness of the dish.
- → Can this pasta be vegetarian?
- Definitely. Swap out chicken for sautéed mushrooms or your go-to meat substitute.
- → What’s the best way to reheat it?
- Warm it gently on the stove or pop it in the microwave. Adding a splash of milk can bring the sauce back to life if it feels too thick.